A small red puppy becomes Clifford, a gigantic dog attracting the attention of a genetics company. As Clifford and his family go on the run he teaches Emily and her uncle the true meaning of acceptance and unconditional love.
As young Emily Elizabeth struggles to fit in at home and at school, she discovers a small red puppy. When Clifford becomes a gigantic red dog in her New York City apartment he attracts the attention of a genetics company who wish to supersize animals, Emily and her clueless Uncle Casey have to fight the forces of greed as they go on the run across the City. Along the way, Clifford affects the lives of everyone around him and teaches Emily and her uncle the true meaning of acceptance and unconditional love.