Meg Murry, a typical middle school student struggling with issues of self-worth is also the intelligent and uniquely gifted daughter of two world-renowned physicists. When her father disappears, Meg, her younger brother Charles and friend Calvin search for him, helped by three celestial guides – Mrs. Which (Oprah Winfrey), Mrs. Whatsit (Reese Witherspoon) and Mrs. Who (Mindy Kaling) who take them travelling via a wrinkling of time and space to confront a powerful evil